Wood Kathryn J, Luo Shiqiao, Akl Ahmed
Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom.
Transplantation. 2004 Jan 15;77(1 Suppl):S6-8. doi: 10.1097/01.TP.0000106477.70852.29.
Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune responsiveness after organ or cell transplantation. In many settings, immunoregulatory activity is enriched in CD4+ T cells that express high levels of CD25, and common mechanisms appear to be responsible for the activity of regulatory T cells in both transplantation and the control of reactivity to self-antigens.
对供体反应性细胞的主动调节或抑制正逐渐成为诱导和维持对供体同种异体抗原无反应性的关键机制。越来越多的证据表明，免疫调节与供体同种异体抗原反应性T细胞的清除之间的平衡能够有效控制器官或细胞移植后的免疫反应性。在许多情况下，免疫调节活性在高表达CD25的CD4+ T细胞中富集，并且常见机制似乎负责调节性T细胞在移植以及对自身抗原反应性控制中的活性。
