Benninger Michael S, Hadley James A, Osguthorpe J David, Marple Bradley F, Leopold Donald A, Derebery M Jennifer, Hannley Maureen
Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Otolaryngol Head Neck Surg. 2004 Jan;130(1):5-24. doi: 10.1016/S0194-5998(03)02085-0.
The effectiveness of topical intranasal steroids (INS) sprays for the treatment of allergic and nonallergic rhinitis may be limited by lack of instruction in the optimal spray technique. To determine whether the technique used affects the efficacy and safety of the product, this review of evidence had the goal of identifying and establishing a preferred method of applying INS sprays.
A MEDLINE search of pertinent literature on 7 INS and 1 intranasal antihistamine spray preparations conducted with the use of appropriate search terms, yielded an initial 121 articles, 29 of which were identified as appropriate for review and grading for quality of evidence.
The analysis provided no definitive evidence regarding how best to instruct patients to use INS or antihistamine spray devices.
On the basis of a lack of clear evidence regarding instructions to maximize efficacy and safety of these drugs, the panel recommended a 7-step standard technique.
局部鼻内用类固醇(INS)喷雾剂治疗变应性和非变应性鼻炎的有效性可能因缺乏最佳喷雾技术指导而受到限制。为确定所使用的技术是否会影响产品的疗效和安全性,本证据综述旨在识别并确立一种应用INS喷雾剂的首选方法。
使用适当的检索词对7种INS和1种鼻内用抗组胺喷雾剂制剂的相关文献进行MEDLINE检索,初步检索到121篇文章,其中29篇被确定适合进行综述并对证据质量进行分级。
分析未提供关于如何最好地指导患者使用INS或抗组胺喷雾装置的确切证据。
基于缺乏关于使这些药物疗效和安全性最大化的使用说明的确切证据,专家组推荐一种7步标准技术。