Ivanisević-Milovanović O K, Musicki B D
Institute for Nuclear Sciences Boris Kidric-Vinca, Department for Molecular Biology and Endocrinology, Belgrade, Yugoslavia.
Endocr Regul. 1992 Jun;26(2):89-93.
Posterior hypothalamic lesions restricted to the mammillary body in newborn rats evoked significantly elevated serum prolactin concentrations (P < 0.05) in adult females in the afternoon of proestrous (16.00 h), while at the same time serum LH values appeared significantly depressed (P < 0.05) as compared to controls. FSH concentrations were not affected. Parallel to changes in hormonal pattern, the ovaries of the lesioned animals grew to excessive dimensions due to the accumulation and persistence of numerous corpora lutea (CL) (syndrome of hyperluteinized ovaries). The results suggest that the posterior hypothalamus can regulate prolactin and LH secretion and that the fate of CL is associated with a quantitative ratio in the circulation of at least two hormones, prolactin and LH.
新生大鼠下丘脑后部局限于乳头体的损伤，在动情前期下午（16:00）使成年雌性大鼠血清催乳素浓度显著升高（P < 0.05），而与此同时，与对照组相比，血清促黄体生成素（LH）值显著降低（P < 0.05）。促卵泡生成素（FSH）浓度未受影响。与激素模式的变化平行，由于大量黄体（CL）的积累和持续存在，损伤动物的卵巢过度增大（高黄体化卵巢综合征）。结果表明，下丘脑后部可调节催乳素和LH的分泌，且CL的命运与循环中至少两种激素——催乳素和LH的定量比例有关。
