大鼠Iddm4与人类7号染色体（HSA7）和小鼠6号染色体（MMU6）上各片段的比较定位。
Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.
作者信息
Hornum Lars, DeScipio Cheryl, Markholst Helle, Troutman Scott A, Novak Stephen, Leif Jean, Greiner Dale, Mordes John P, Blankenhorn Elizabeth P
机构信息
Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark.
出版信息
Mamm Genome. 2004 Jan;15(1):53-61. doi: 10.1007/s00335-003-3023-z.
Iddm4 is one of several susceptibility genes that have been identified in the BB rat model of type 1 diabetes. The BB rat allele of this gene confers dominant predisposition to diabetes induction by immune perturbation in both the diabetes-prone and the diabetes-resistant substrains, whereas the Wistar Furth (WF) allele confers resistance. We have positioned the gene in a 2.8-cM region on rat Chromosome (Chr) 4, proximal to Lyp/Ian4l1. We have produced a radiation hybrid map of the Iddm4-region that includes a number of rat genes with their mouse and human orthologs. We present a comparative map of the rat Iddm4 region in rat, human, and mouse, assigning the gene to a 6.3-Mb segment between PTN and ZYX at 7q32 in the human genome, and to a 5.7-Mb segment between Ptn and Zyx in the mouse genome.
Iddm4是在1型糖尿病的BB大鼠模型中已鉴定出的几个易感基因之一。该基因的BB大鼠等位基因在糖尿病易感和糖尿病抗性亚系中均赋予通过免疫扰动诱导糖尿病的显性易感性，而Wistar Furth（WF）等位基因则赋予抗性。我们已将该基因定位在大鼠4号染色体（Chr）上一个2.8厘摩的区域，靠近Lyp/Ian4l1。我们构建了Iddm4区域的辐射杂种图谱，其中包括许多具有小鼠和人类直系同源基因的大鼠基因。我们展示了大鼠、人类和小鼠中大鼠Iddm4区域的比较图谱，将该基因定位到人类基因组7q32处PTN和ZYX之间的一个6.3兆碱基片段，以及小鼠基因组中Ptn和Zyx之间的一个5.7兆碱基片段。
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