Cai Rui-Fen, Cui Yu-Gui, Hua Li-Xin, Jia Yue, Ma Ding-Zhi, Wang Xing-Hai
Jiangsu Family Planning Institute, Nanjing, Jiangsu 210036, China.
Zhonghua Nan Ke Xue. 2003 Dec;9(9):651-3, 657.
To investigate the pathoanatomize histological and biochemical characteristics of benign prostatic hyperplasia (BPH) by use of old dogs with spontaneous BPH as animal models.
Old dogs aged 6 to 13 years were recruited after anus check, B-ultrasonic examination by recta spy and measurement under surgical exploration. Ten dogs with notable prostatic hyperplasia were used as models, and 6 with non-hyperplasia prostate as control. Serum testosterone (T), estrogen (E2), ACP and prostatic specific antigen (PSA) were analyzed, and prostates were checked histologically.
Prostate volume of the BPH group was significantly bigger than those of the control group, (14.7 +/- 2.3) and (13.8 +/- 1.9) cm3 vs (8.4 +/- 1.0) and (8.4 +/- 1.9) cm3, P < 0.01. Serum T [(14.3 +/- 2.9) vs (16.4 +/- 4.0) nmol/L] and E2 [(137.6 +/- 70.8) vs (164.4 +/- 82.0) pmol/L] were not different between the two groups (P > 0.05). ACP of the BPH group was higher than that of the control group [(6.63 +/- 2.76) vs (4.92 +/- 2.19) U/L], but the difference was not statistically significant (P > 0.05). There was significant difference between the BPH group and the control group in PSA level [(5.6 +/- 0.78) vs (3.1 +/- 0.54) microgram/L, P < 0.01]. The tissue slides of the BPH prostates showed hyperplasia with raised height of epithelium, and many long and offsetting mammillae in the gland cavity due to epithelium hyperplasia.
Old dogs with spontaneous BPH are useful animal models for the etiological and pharmacological researches of human BPH.
以自发性良性前列腺增生（BPH）的老龄犬作为动物模型，研究BPH的病理解剖、组织学及生化特征。
选取6至13岁的老龄犬，经肛门检查、直肠超声检查及手术探查测量后纳入研究。将10只前列腺明显增生的犬作为模型，6只前列腺未增生的犬作为对照。分析血清睾酮（T）、雌激素（E2）、酸性磷酸酶（ACP）和前列腺特异性抗原（PSA），并对前列腺进行组织学检查。
BPH组前列腺体积显著大于对照组，（14.7±2.3）和（13.8±1.9）cm³ 对比（8.4±1.0）和（8.4±1.9）cm³，P<0.01。两组血清T[（14.3±2.9）对比（16.4±4.0）nmol/L]和E2[（137.6±70.8）对比（164.4±82.）pmol/L]无差异（P>0.05）。BPH组ACP高于对照组[（6.63±2.76）对比（4.92±2.19）U/L]，但差异无统计学意义（P>0.05）。BPH组与对照组PSA水平有显著差异[（5.6±0.78）对比（3.1±0.54）μg/L，P<0.01]。BPH前列腺组织切片显示上皮高度增加的增生，腺腔内因上皮增生有许多长而交错的乳头。
自发性BPH老龄犬是人类BPH病因学和药理学研究的有用动物模型。
