[委内瑞拉苏利亚州混血患者中HLA I类与白血病的关联]

[Association of HLA class I and leukemia in mestizo patients of the state of Zulia, Venezuela].

作者信息

Villalobos Carmen, Rivera Sergio, Weir-Medina Jesús, Hassanhi Manzur, Montiel Milagros, González Romer

机构信息

Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.

出版信息

Invest Clin. 2003 Dec;44(4):283-9.

PMID:14727382

Abstract

The Human Leukocyte Allele (HLA) Class I (A, B, C) and Acute Lymphoid Leukemia and Myeloid Leukemia association, was determined by polymerase chain reaction--sequence specific primers (PCR-SSP) in 60 patients and 30 healthy controls. The results were reported as allelic frequencies and haplotype. The Chi-square corrected, Fisher's Test, Relative risk and etiologic fraction were calculated. A significant positive association was showed between HLA-B39 (RR = 16.184; p = 0.0237) and HLA C03 (RR = 5.0; p = 0.0127) alleles and Mycloid Leukaemia. Positive associations between haplotypes 2 loci: HLA-A02-C03 (RR = 6.0; p = 0.0153), A24-C03 (RR = 16.184; p = 0.0237), B40-C03 (RR = 10.706; p = 0.0021) and haplotype 3 loci: HLA-A02-B40-C*03 (RR = 8.11; p = 0.0102) and Myeloid Leukemia were found. No association was evident in Acute Lymphoid Leukemia. No negative association with Leukemias were observed.

摘要

采用聚合酶链反应-序列特异性引物（PCR-SSP）法，对60例患者和30名健康对照者进行人类白细胞抗原（HLA）Ⅰ类（A、B、C）与急性淋巴细胞白血病和髓系白血病相关性的检测。结果以等位基因频率和单倍型形式报告，并计算校正卡方检验、Fisher检验、相对风险和病因分数。结果显示，HLA-B39（RR = 16.184；p = 0.0237）和HLA C03（RR = 5.0；p = 0.0127）等位基因与髓系白血病之间存在显著正相关。单倍型2个位点HLA-A02-C03（RR = 6.0；p = 0.0153）、A24-C03（RR = 16.184；p = 0.0237）、B40-C03（RR = 10.706；p = 0.0021）以及单倍型3个位点HLA-A02-B40-C*03（RR = 8.11；p = 0.0102）与髓系白血病之间也存在正相关。在急性淋巴细胞白血病中未发现明显相关性。未观察到与白血病的负相关。