Chukwuma C
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.
J Diabetes Complications. 1992 Jul-Sep;6(3):197-202. doi: 10.1016/1056-8727(92)90036-k.
In type I diabetes, the quality of life and, in essence, the long-term prognosis or life expectancy of the patient are invariably related to the manifestation of untoward complications. Increased arterial blood pressure (hypertension) has a great influence in these complications. Cumulative evidence has shown that proteinuric type I diabetic patients are easily susceptible to hypertension and its accompanying sequelae. The debilitating effects of hypertension on the progressive development of diabetic nephropathy leading to renal dysfunction and mortality in renal transplant patients have been documented. Proliferative retinopathy and cardiovascular lesions are also frequent devastating complications in hypertensive-diabetic patients. The mechanism of sodium/lithium countertransport activity and the genetic predisposition to hypertension require further elucidation.
在1型糖尿病中，患者的生活质量以及本质上的长期预后或预期寿命总是与不良并发症的表现相关。动脉血压升高（高血压）对这些并发症有很大影响。累积证据表明，蛋白尿型1型糖尿病患者很容易患高血压及其伴随的后遗症。高血压对糖尿病肾病进展导致肾功能不全以及肾移植患者死亡的削弱作用已有文献记载。增殖性视网膜病变和心血管病变也是高血压糖尿病患者常见的严重并发症。钠/锂逆向转运活性机制以及高血压的遗传易感性需要进一步阐明。
