Gallagher J T, Turnbull J E
Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK.
Glycobiology. 1992 Dec;2(6):523-8. doi: 10.1093/glycob/2.6.523.
Heparan sulphate proteoglycans (HSPGs) are widely distributed in animal tissues, but their most prominent locations are cell surface membranes and basement membranes. Their influence on various fundamental aspects of cell behaviour (e.g. cell adhesion, growth and morphogenesis) are dependent on the specific binding properties of the heparan sulphate (HS) chains. These polysaccharides are complex structures in which N-sulphated glucosamine and ester sulphate groups tend to be clustered in discrete regions of the chain separated by sequences enriched in N-acetylglucosamine residues, but with a low sulphate concentration. The sulphated domains contain the sugar residue sequences for interaction with specific proteins essential for HS function. In this review, we describe the plasma membrane HSPGs and their role in regulating the activity of basic fibroblast growth factor (bFGF).
硫酸乙酰肝素蛋白聚糖（HSPGs）广泛分布于动物组织中，但其最主要的分布位置是细胞表面膜和基底膜。它们对细胞行为的各个基本方面（如细胞黏附、生长和形态发生）的影响取决于硫酸乙酰肝素（HS）链的特定结合特性。这些多糖结构复杂，其中N-硫酸化葡糖胺和硫酸酯基团倾向于聚集在链的离散区域，这些区域被富含N-乙酰葡糖胺残基但硫酸盐浓度较低的序列隔开。硫酸化结构域包含与HS功能所必需的特定蛋白质相互作用的糖残基序列。在本综述中，我们描述了质膜HSPGs及其在调节碱性成纤维细胞生长因子（bFGF）活性中的作用。
