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八阶段安德森非存活撞击器预分离器性能评估

Evaluation of preseparator performance for the 8-stage nonviable andersen impactor.

作者信息

Sethuraman V V, Hickey A J

机构信息

School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

出版信息

AAPS PharmSciTech. 2001 Mar 26;2(1):E4. doi: 10.1208/pt020104.

Abstract

The preseparator of an Andersen impactor with different coating treatments for a range of particle-size distributions was evaluated. Limited theoretical simulations constrained by simplifying assumptions of the airflow fields in the preseparator and upper stages of an 8-stage Andersen impactor were used to reveal low-velocity and high-pressure regions for potential deposition. These regions were then sampled in subsequent particle deposition experiments. Disodium fluorescein aerosols were sampled with different coating treatments of the preseparator floor. Particles collected at impactor stages determined particle size distributions. Stage deposition was compared between different preseparator treatments (buffer and silicon oil). Collection efficiency in the preseparator followed the pattern buffer > silicon oil > untreated. Statistical differences (P < 0.05) were noted in collection efficiency of large particles (45 micro m-75 microm) in the preseparator. The mass median aerodynamic diameters and geometric standard deviations showed some statistical differences when different preseparator treatments for large particles were used; therefore, preseparator coating was shown to influence performance and thereby estimates of particle size by inertial impaction.

摘要

对具有不同涂层处理的安德森撞击器预分离器在一系列粒径分布情况下进行了评估。通过对八级安德森撞击器预分离器和上级气流场进行简化假设的有限理论模拟,揭示潜在沉积的低速和高压区域。然后在后续的颗粒沉积实验中对这些区域进行采样。用预分离器底板的不同涂层处理对荧光素二钠气溶胶进行采样。在撞击器各级收集的颗粒确定粒径分布。比较了不同预分离器处理(缓冲液和硅油)之间的级沉积情况。预分离器中的收集效率遵循缓冲液>硅油>未处理的模式。在预分离器中,大颗粒(45微米 - 75微米)的收集效率存在统计学差异(P < 0.05)。当对大颗粒使用不同的预分离器处理时,质量中值空气动力学直径和几何标准差显示出一些统计学差异;因此,预分离器涂层被证明会影响性能,进而影响通过惯性撞击对粒径的估计。

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