Nelson Mark R, Reid Chris M, Krum Henry, McNeil John J
Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Prahran, Australia.
Am J Cardiovasc Drugs. 2003;3(6):437-41. doi: 10.2165/00129784-200303060-00006.
Family physicians do not prescribe antihypertensive medication according to current guidelines. This study investigates possible reasons for this. The objectives were to measure the knowledge, attitude and stated practice of family physicians to the initiation of pharmacotherapy for uncomplicated hypertension and to explore the reasons why clinical practice differs from guideline recommendations.
A cross-sectional postal survey conducted between June and October 1999. Simple frequency analysis and a chi(2) test comparing family physician characteristics and responses.
A three-phase postal survey was undertaken of a random sample of family physicians. Telephone and facsimile contact was made to non-responders. The survey instrument included respondent characteristics, preference for initiation of antihypertensive drug therapy and their opinion of efficacy, adverse effects and long-term safety, as well as knowledge of guidelines.
Family physicians in the state of Victoria, Australia.
Ranked preference of drugs for uncomplicated hypertension. Opinion of drug efficacy, adverse effects, safety and cost. Knowledge of guidelines for first-line antihypertensive drugs. Newer agents are preferred to older agents in the initiation of antihypertensive drug therapy contrary to current guideline recommendations. Newer agents were thought to be more efficacious, have better short- and long-term adverse effect profiles and be more expensive than older agents. Younger doctors most often held these attitudes. Guidelines influenced decision making but were not the most important factor.
There is a demonstrable need for governments to invest in the promotion of accurate information on drugs through continuing education of prescribers and facilitating the production of standardized paper and web-based clinical guidelines. A program of targeted investment in clinical trials that examine the justification for more expensive classes of agents should also be considered in appropriate circumstances.
家庭医生并未按照当前指南开具抗高血压药物。本研究调查了其中可能的原因。目的是衡量家庭医生对于单纯性高血压药物治疗起始的知识、态度和既定做法,并探究临床实践与指南推荐不同的原因。
1999年6月至10月进行的一项横断面邮寄调查。采用简单频率分析和卡方检验比较家庭医生的特征和反应。
对家庭医生随机样本进行了三阶段邮寄调查。对未回复者进行了电话和传真联系。调查工具包括受访者特征、抗高血压药物治疗起始的偏好及其对疗效、不良反应和长期安全性的看法,以及对指南的了解。
澳大利亚维多利亚州的家庭医生。
单纯性高血压药物的排名偏好。对药物疗效、不良反应、安全性和成本的看法。一线抗高血压药物指南的知识。与当前指南推荐相反,在抗高血压药物治疗起始时,新型药物比旧型药物更受青睐。新型药物被认为更有效,短期和长期不良反应谱更好,但比旧型药物更昂贵。年轻医生最常持有这些态度。指南影响决策,但不是最重要的因素。
政府显然有必要通过对开处方者进行继续教育并促进编制标准化的纸质和基于网络的临床指南,来投资推广关于药物的准确信息。在适当情况下,还应考虑开展一项有针对性的临床试验投资计划,以审查更昂贵药物类别的合理性。