Gavin Andrew R, Struthers Allan D
Department of Clinical Pharmacology, Ninewells Hospital, Dundee DD1 9SY, Scotland.
Am J Cardiovasc Drugs. 2003;3(5):309-14. doi: 10.2165/00129784-200303050-00001.
High uric acid levels are associated with increased morbidity and mortality rates in cardiovascular disease. In this article we explore the relationship between cardiovascular disease and xanthine oxidase activity. We look at the evidence that uric acid and its production via the xanthine oxidase pathway, may directly contribute to this increased cardiovascular risk. We examine the relationship between uric acid and other established cardiovascular risk factors and look at the evidence that reducing uric acid production may have a beneficial impact on cardiovascular morbidity and mortality. We conclude that although there is currently insufficient evidence to recommend the routine use of xanthine oxidase inhibitors in those with cardiovascular disease and asymptomatic hyperuricemia, there is sufficient evidence to warrant a large scale morbidity and mortality trial.
高尿酸水平与心血管疾病的发病率和死亡率增加相关。在本文中，我们探讨心血管疾病与黄嘌呤氧化酶活性之间的关系。我们审视了尿酸及其通过黄嘌呤氧化酶途径生成可能直接导致心血管风险增加的证据。我们研究尿酸与其他已确定的心血管危险因素之间的关系，并审视降低尿酸生成可能对心血管发病率和死亡率产生有益影响的证据。我们得出结论，尽管目前尚无足够证据推荐在患有心血管疾病和无症状高尿酸血症的患者中常规使用黄嘌呤氧化酶抑制剂，但有足够证据值得开展一项大规模的发病率和死亡率试验。
