用于基因组组装的C.A.Ve.软件工具。
The C.A.Ve. software tool for genome assembly.
作者信息
Sivam Dhileepan, Myler Peter
机构信息
University of Washington, Seattle, WA, USA.
出版信息
AMIA Annu Symp Proc. 2003;2003:1009.
Misassembly due to the presence of repetitive DNA sequences often complicates the contig assembly stage of genome sequencing. Accurate physical representations of chromosomes, such as restriction maps or contig maps, provide a means for validating the sequence assembly and clarifying alignment ambiguity. The Contig Assembly Verifier (CAVe) software tool allows the researcher to automatically reconcile a sequence assembly with a physical representation, and, if needed, to modify the assembly using an intuitive graphical user interface.
由于存在重复DNA序列导致的错误组装常常使基因组测序的重叠群组装阶段变得复杂。染色体的精确物理表示，如限制酶切图谱或重叠群图谱，为验证序列组装和澄清比对歧义提供了一种方法。重叠群组装验证器（CAVe）软件工具使研究人员能够自动将序列组装与物理表示进行比对，并且如果需要，可使用直观的图形用户界面修改组装结果。
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