Sloan Frank A, Trogdon Justin G, Curtis Lesley H, Schulman Kevin A
Department of Economics and Clinical Research Institute, Duke University, Durham, North Carolina 27708, USA.
J Am Geriatr Soc. 2004 Feb;52(2):173-81. doi: 10.1111/j.1532-5415.2004.52052.x.
To determine differences in mortality after admission for acute myocardial infarction (AMI) and in use of noninvasive and invasive treatments for AMI between patients with and without dementia.
Retrospective chart review.
Cooperative Cardiovascular Project.
Medicare patients admitted for AMI (N=129,092) in 1994 and 1995.
Dementia noted on medical chart as history of dementia, Alzheimer's disease, chronic confusion, or senility. Outcome measures included mortality at 30 days and 1-year postadmission; use of aspirin, beta-blocker, angiotensin-converting enzyme (ACE) inhibitor, thrombolytic therapy, cardiac catheterization, coronary angioplasty, and cardiac bypass surgery compared by dementia status.
Dementia was associated with higher mortality at 30 days (relative risk (RR)=1.16, 95% confidence interval (CI)=1.09-1.22) and at 1-year postadmission (RR=1.18, 95% CI=1.13-1.23). There were few to no differences in the use of aspirin and beta-blockers between patients with and without a history of dementia. Patients with a history of dementia were less likely to receive ACE inhibitors during the stay (RR=0.89, 95% CI=0.86-0.93) or at discharge (RR=0.90, 95% CI=0.86-0.95), thrombolytic therapy (RR=0.82, 95% CI=0.74-0.90), catheterization (RR=0.51, 95% CI=0.47-0.55), coronary angioplasty (RR=0.58, 95% CI=0.51-0.66), and cardiac bypass surgery (RR=0.41, 95% CI=0.33-0.50) than patients without a history of dementia.
The results imply that the presence of dementia had a major effect on mortality and care patterns for this condition.
确定急性心肌梗死(AMI)入院后痴呆患者与非痴呆患者在死亡率以及AMI无创和有创治疗使用方面的差异。
回顾性病历审查。
心血管合作项目。
1994年和1995年因AMI入院的医疗保险患者(N = 129,092)。
病历中记录的痴呆病史,如痴呆、阿尔茨海默病、慢性意识模糊或衰老。结局指标包括入院后30天和1年时的死亡率;根据痴呆状态比较阿司匹林、β受体阻滞剂、血管紧张素转换酶(ACE)抑制剂、溶栓治疗、心脏导管插入术、冠状动脉血管成形术和心脏搭桥手术的使用情况。
痴呆与30天时较高的死亡率相关(相对风险(RR)= 1.16,95%置信区间(CI)= 1.09 - 1.22)以及入院后1年时较高的死亡率相关(RR = 1.18,95% CI = 1.13 - 1.23)。有痴呆病史和无痴呆病史的患者在阿司匹林和β受体阻滞剂的使用上几乎没有差异。有痴呆病史的患者在住院期间(RR = 0.89,95% CI = 0.86 - 0.93)或出院时(RR = 0.90,95% CI = 0.86 - 0.95)接受ACE抑制剂治疗的可能性较小,接受溶栓治疗(RR = 0.82,95% CI = 0.74 - 0.90)、导管插入术(RR = 0.51,95% CI = 0.47 - 0.55)、冠状动脉血管成形术(RR = 0.58,95% CI = 0.51 - 0.66)和心脏搭桥手术(RR = 0.41,95% CI = 0.33 - 0.50)的可能性也低于无痴呆病史的患者。
结果表明痴呆的存在对这种疾病的死亡率和护理模式有重大影响。