膳食植物雌激素可下调大鼠前列腺中的雄激素受体表达。
Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens.
作者信息
Lund Trent D, Munson Daniel J, Adlercreutz Herman, Handa Robert J, Lephart Edwin D
机构信息
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
出版信息
Reprod Biol Endocrinol. 2004 Jan 16;2:5. doi: 10.1186/1477-7827-2-5.
Abstract
BACKGROUND
It is well established that the growth of the prostate gland is a hormone-dependent phenomenon involving both androgenic and estrogenic control. Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate.
METHODS
The prostates of male Long-Evans rats fed a diet high in phytoestrogens (Phyto-600) or very low levels of phytoestrogens (Phyto-free) were analyzed to determine the impact of dietary phytoestrogens on prostate weight and androgen receptor (AR) expression in the prostate.
RESULTS
Dietary phytoestrogens significantly decreased post-pubertal prostate weight gain in Phyto-600 vs Phyto-free fed males. Additionally, dietary phytoestrogens (Phyto-600) decreased AR expression in the prostate as determined by in situ hybridization.
CONCLUSIONS
Soy phytoestrogens, present in diet, alter prostate growth presumably by binding ER-beta and subsequently reducing AR expression within the prostate.
摘要
背景
前列腺的生长是一种激素依赖性现象，涉及雄激素和雌激素的控制，这一点已得到充分证实。前列腺细胞的增殖至少部分受雌激素受体β（ER-β）的控制。植物雌激素与ER-β具有高亲和力结合，因此可能对前列腺具有抗增殖作用。
方法
分析喂食高植物雌激素饮食（Phyto-600）或极低植物雌激素饮食（无植物雌激素）的雄性Long-Evans大鼠的前列腺，以确定饮食中的植物雌激素对前列腺重量和前列腺中雄激素受体（AR）表达的影响。
结果
与喂食无植物雌激素饮食的雄性大鼠相比，喂食Phyto-600的大鼠青春期后前列腺重量增加显著减少。此外，通过原位杂交确定，饮食中的植物雌激素（Phyto-600）可降低前列腺中的AR表达。
结论
饮食中存在的大豆植物雌激素可能通过与ER-β结合，进而降低前列腺内AR表达，从而改变前列腺生长。
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