Shi Hong-hui, Yang Xiu-yu, Xiang Yang, Wan Xi-run, Luo Li-bing, Li Ling, Liu Ming-rui
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
Zhonghua Fu Chan Ke Za Zhi. 2003 Dec;38(12):756-8.
To evaluate the effect of serum/cerebrospinal fluid (CSF) ratio of human chorionic gonadotropin (hCG) in detecting brain metastases of gestational trophoblast tumor and the significance of prophylactic intrathecal therapy.
Clinical information of 44 patients with brain metastases (stage IV) and 29 patients with lung metastases (stage III) of gestational trophoblast tumor who were admitted to our hospital between 1986 to 2001 were retrospectively analyzed by case control study. The variability of the ratio and the relationship between brain metastases was investigated, together with the effect of prophylactic intrathecal therapy.
Serum/CSF hCG ratio in patients with brain metastases declined with time. The ratio before chemotherapy was in relevant with the size of the lesion which were less than 60 in advanced stages and more than 60 in early stages. Patients of stage III with prophylactic intrathecal therapy did not progress to stage IV.
Serum/CSF hCG ratio before chemotherapy could reflect the encephalic tumor load which had reference value in diagnosis and prognosis and prophylactic intrathecal therapy played an important role in preventing brain metastasis.
评估人绒毛膜促性腺激素（hCG）血清/脑脊液（CSF）比值在检测妊娠滋养细胞肿瘤脑转移中的作用及鞘内预防性治疗的意义。
采用病例对照研究方法，回顾性分析1986年至2001年我院收治的44例妊娠滋养细胞肿瘤脑转移（IV期）患者和29例肺转移（III期）患者的临床资料。研究该比值的变化及其与脑转移的关系，以及鞘内预防性治疗的效果。
脑转移患者血清/CSF hCG比值随时间下降。化疗前该比值与病灶大小相关，晚期小于60，早期大于60。接受鞘内预防性治疗的III期患者未进展至IV期。
化疗前血清/CSF hCG比值可反映脑肿瘤负荷，对诊断和预后有参考价值，鞘内预防性治疗在预防脑转移中起重要作用。
