Fisher Anna E O, Naughton Declan P
School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewis Road, Cockcroft Building, Moulsecoomb, Brighton BN2 4GJ, UK.
J Inorg Biochem. 2004 Feb;98(2):343-6. doi: 10.1016/j.jinorgbio.2003.11.003.
The cupric ion binding characteristics of the chelator EDTA bis (ethyl tyrosinate) are reported. Potentiometric studies in aqueous solutions over the pH range of 2.0-12.0 allowed identification and quantification of the species in solution. The principal species CuA predominates over the physiological pH range of 4.0-8.0 pH units. The logarithm of the stability constant (log beta(pqr)) for this species is 16.43. The cupric ion binding characteristics were further assessed using electronic absorption spectroscopic investigations. These results support the use of this chelator as a metal binding anti-oxidant.
报道了螯合剂乙二胺四乙酸双（乙基酪氨酸酯）的铜离子结合特性。在2.0 - 12.0的pH范围内对水溶液进行电位滴定研究，从而对溶液中的物种进行鉴定和定量。主要物种CuA在4.0 - 8.0 pH单位的生理pH范围内占主导地位。该物种的稳定常数对数（log beta(pqr)）为16.43。使用电子吸收光谱研究进一步评估了铜离子结合特性。这些结果支持将这种螯合剂用作金属结合抗氧化剂。
