肾小球血管紧张素II受体亚型的特征分析
Characterization of glomerular angiotensin II receptor subtypes.
作者信息
Gauquelin G, Garcia R
机构信息
Laboratory of Experimental Hypertension and Vasoactive Peptides, Clinical Research Institute of Montreal, Quebec, Canada.
出版信息
Receptor. 1992 Fall;2(3):207-12.
Radioligand-receptor binding techniques identified two angiotensin II (ANG II) receptor subtypes in rat renal glomerular membranes. This characterization was made possible by employing two highly-specific nonpeptide ANG II antagonists: Losartan (DuP 753), which is specific to the AT1 subtype, and PD 123319, which is specific to the AT2 subtype. The majority of ANG II receptors in glomerular membranes corresponded to the AT1 subtype.
放射性配体-受体结合技术在大鼠肾小球膜中鉴定出两种血管紧张素II（ANG II）受体亚型。通过使用两种高度特异性的非肽类ANG II拮抗剂，这种特性得以确定：氯沙坦（DuP 753），它对AT1亚型具有特异性；以及PD 123319，它对AT2亚型具有特异性。肾小球膜中的大多数ANG II受体对应于AT1亚型。
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