两性霉素B脂质体和两性霉素B在播散性曲霉病小鼠模型中的疗效比较研究。
Comparative studies on the efficacy of AmBisome and Fungizone in a mouse model of disseminated aspergillosis.
作者信息
Takemoto Koji, Yamamoto Yutaka, Ueda Yutaka, Sumita Yoshihiro, Yoshida Koichiro, Niki Yoshihito
机构信息
Sumitomo Pharmaceuticals Research Division, 1-98, Kasugadenaka 3-chome, Konohana-ku, Osaka 554-0022, Japan.
出版信息
J Antimicrob Chemother. 2004 Feb;53(2):311-7. doi: 10.1093/jac/dkh055. Epub 2004 Jan 16.
OBJECTIVES
The efficacy of intravenous injections of a liposomal formulation of amphotericin B (AmBisome) and amphotericin B deoxycholate (Fungizone) was evaluated in immunocompetent and temporarily leucopenic mouse models of disseminated aspergillosis using seven isolates of Aspergillus.
METHODS
Mice were infected with the organisms via tail veins. At 4 h after infection, antifungals were administered intravenously. For 30 days the number of mice surviving was recorded.
RESULTS
AmBisome at 1 mg/kg or higher significantly prolonged the survival time of mice infected with five out of seven isolates of Aspergillus compared with the control group. There was no difference in in vivo activity between AmBisome and Fungizone at 1 mg/kg in six isolates of Aspergillus. At the maximum tolerated dose of antifungals, however, AmBisome (10 mg/kg) showed greater efficacy than Fungizone (1 mg/kg).
CONCLUSIONS
These results suggest that the overall protective activity of AmBisome against disseminated aspergillosis is superior to that of Fungizone.
目的
使用七种曲霉菌株，在免疫功能正常和暂时白细胞减少的播散性曲霉病小鼠模型中，评估两性霉素B脂质体制剂（安必素）和两性霉素B脱氧胆酸盐（两性霉素B）静脉注射的疗效。
方法
通过尾静脉将这些微生物感染小鼠。感染后4小时，静脉注射抗真菌药物。记录30天内存活小鼠的数量。
结果
与对照组相比，1mg/kg或更高剂量的安必素显著延长了感染七种曲霉菌株中五种的小鼠的存活时间。在六种曲霉菌株中，1mg/kg的安必素和两性霉素B的体内活性没有差异。然而，在抗真菌药物的最大耐受剂量下，安必素（10mg/kg）比两性霉素B（1mg/kg）显示出更大的疗效。
结论
这些结果表明，安必素对播散性曲霉病的总体保护活性优于两性霉素B。
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