Mieno Hideki, Fujimoto Norihiro, Tajima Shingo
Department of Dermatology, National Defense Medical College, Tokorozawa, Japan.
Dermatology. 2004;208(1):67-9. doi: 10.1159/000075050.
Two cases of eruptive vellus hair cysts associated with chronic renal failure are reported. Histologically the lesions of both cases showed cystic structures in the dermis lined by squamous epithelium which contained varying amounts of vellus hair shafts. Immunohistochemical studies using monoclonal anti-AGE (advanced glycation end product) antibody demonstrated that keratinous materials within the cystic structures were immunoreactive to the antibody, whereas those of cystic lesions (epidermal cyst, eruptive vellus hair cyst, steatocystoma multiplex, trichofolliculoma and trichilemmal cyst) seen in otherwise healthy individuals were negative. Because it has been reported that plasma and skin levels of AGE are elevated in renal failure patients, AGE-modified keratinous materials may be associated with the formation of cystic structures by stimulating the occlusion of the epithelium.
报告了两例与慢性肾衰竭相关的发疹性毳毛囊肿。组织学上，两例病变均显示真皮内有由鳞状上皮衬里的囊性结构，其中含有不同数量的毳毛干。使用单克隆抗晚期糖基化终末产物（AGE）抗体进行的免疫组织化学研究表明，囊性结构内的角质物质对该抗体呈免疫反应性，而在其他方面健康个体中所见的囊性病变（表皮囊肿、发疹性毳毛囊肿、多发性皮脂囊肿、毛囊瘤和毛鞘囊肿）的角质物质则为阴性。因为有报道称肾衰竭患者血浆和皮肤中的AGE水平升高，所以AGE修饰的角质物质可能通过刺激上皮细胞的阻塞而与囊性结构的形成有关。
