用（68）Ga-DOTATOC PET显像发现胰腺神经内分泌肿瘤中生长抑素受体表达异常增加。 - Suppr

Exceptional increase in somatostatin receptor expression in pancreatic neuroendocrine tumour, visualised with (68)Ga-DOTATOC PET.

作者信息

Henze Marcus, Schuhmacher Jochen, Dimitrakopoulou-Strauss Antonia, Strauss Ludwig G, Mäcke Helmut R, Eisenhut Michael, Haberkorn Uwe

机构信息

Clinical Cooperation Unit, Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany.

出版信息

Eur J Nucl Med Mol Imaging. 2004 Mar;31(3):466. doi: 10.1007/s00259-003-1436-2. Epub 2004 Jan 17.

DOI:10.1007/s00259-003-1436-2

PMID:14730407

Abstract

摘要

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Exceptional increase in somatostatin receptor expression in pancreatic neuroendocrine tumour, visualised with (68)Ga-DOTATOC PET.用（68）Ga-DOTATOC PET显像发现胰腺神经内分泌肿瘤中生长抑素受体表达异常增加。

Eur J Nucl Med Mol Imaging. 2004 Mar;31(3):466. doi: 10.1007/s00259-003-1436-2. Epub 2004 Jan 17.

Current knowledge on the sensitivity of the (68)Ga-somatostatin receptor positron emission tomography and the SUVmax reference range for management of pancreatic neuroendocrine tumours.关于（68）镓-生长抑素受体正电子发射断层扫描的敏感性以及用于胰腺神经内分泌肿瘤管理的SUVmax参考范围的当前知识。

Eur J Nucl Med Mol Imaging. 2016 Oct;43(11):2072-83. doi: 10.1007/s00259-016-3395-4. Epub 2016 May 13.

Ga-66 labeled somatostatin analogue DOTA-DPhe1-Tyr3-octreotide as a potential agent for positron emission tomography imaging and receptor mediated internal radiotherapy of somatostatin receptor positive tumors.镓-66标记的生长抑素类似物DOTA-DPhe1-Tyr3-奥曲肽作为一种潜在的正电子发射断层显像剂及生长抑素受体阳性肿瘤的受体介导内放射治疗药物。

Nucl Med Biol. 2002 Feb;29(2):147-57. doi: 10.1016/s0969-8051(01)00290-6.

Prospective Within-Patient Assessment of the Impact of an Unlabeled Octreotide Pre-dose on the Biodistribution and Tumor Uptake of Ga DOTATOC as Assessed by Dynamic Whole-body PET in Patients with Neuroendocrine Tumors: Implications for Diagnosis and Therapy.前瞻性患者内评估未标记的奥曲肽预给药对神经内分泌肿瘤患者动态全身PET评估的镓[68Ga] DOTATOC生物分布和肿瘤摄取的影响：对诊断和治疗的意义

Mol Imaging Biol. 2021 Oct;23(5):766-774. doi: 10.1007/s11307-021-01600-5. Epub 2021 Apr 7.

Comparison of 68Ga-DOTATOC biodistribution in patients with and without spleenectomy.有脾切除术和无脾切除术患者的68Ga-DOTATOC生物分布比较。

Q J Nucl Med Mol Imaging. 2015 Mar;59(1):116-20. Epub 2013 Dec 17.

Differential uptake of (68)Ga-DOTATOC and (68)Ga-DOTATATE in PET/CT of gastroenteropancreatic neuroendocrine tumors.(68)Ga-DOTATOC与(68)Ga-DOTATATE在胃肠胰神经内分泌肿瘤PET/CT中的摄取差异

Recent Results Cancer Res. 2013;194:353-71. doi: 10.1007/978-3-642-27994-2_18.

In vivo binding of [68Ga]-DOTATOC to somatostatin receptors in neuroendocrine tumours--impact of peptide mass.体内 [68Ga]-DOTATOC 与神经内分泌肿瘤中生长抑素受体的结合——肽质量的影响。

Nucl Med Biol. 2010 Apr;37(3):265-75. doi: 10.1016/j.nucmedbio.2009.11.008. Epub 2010 Jan 15.

Should we stop offering indium-111 octreotide scans in favour of gallium-68 PET-CT scans in the UK?在英国，我们是否应该停止提供铟-111奥曲肽扫描，转而采用镓-68正电子发射断层扫描-计算机断层扫描（PET-CT）？

Nucl Med Commun. 2016 Dec;37(12):1221-1222. doi: 10.1097/MNM.0000000000000596.

Biokinetics and imaging with the somatostatin receptor PET radioligand (68)Ga-DOTATOC: preliminary data.生长抑素受体PET放射性配体（68）Ga-DOTATOC的生物动力学与成像：初步数据

Eur J Nucl Med. 2001 Dec;28(12):1751-7. doi: 10.1007/s002590100639. Epub 2001 Oct 31.

Somatostatin-receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors.基于生长抑素受体的胃肠胰神经内分泌肿瘤的影像学诊断与治疗。

Endocr Relat Cancer. 2010 Jan 29;17(1):R53-73. doi: 10.1677/ERC-09-0078. Print 2010 Mar.

引用本文的文献

Imaging of gastroenteropancreatic neuroendocrine tumors.胃肠胰神经内分泌肿瘤的影像学检查

World J Clin Oncol. 2011 Jan 10;2(1):28-43. doi: 10.5306/wjco.v2.i1.28.

68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer.68Ga 标记的前列腺特异性膜抗原（PSMA）抑制剂用于前列腺癌成像。

J Med Chem. 2010 Jul 22;53(14):5333-41. doi: 10.1021/jm100623e.

Radiolabeled cyclic RGD peptides as integrin alpha(v)beta(3)-targeted radiotracers: maximizing binding affinity via bivalency.放射性标记的环状 RGD 肽作为整合素 α(v)β(3)靶向放射性示踪剂：通过双价作用最大化结合亲和力。

Bioconjug Chem. 2009 Dec;20(12):2199-213. doi: 10.1021/bc900167c.

Synthesis and biodistribution of lipophilic and monocationic gallium radiopharmaceuticals derived from N,N'-bis(3-aminopropyl)-N,N'-dimethylethylenediamine: potential agents for PET myocardial imaging with 68Ga.源自N,N'-双(3-氨丙基)-N,N'-二甲基乙二胺的亲脂性单阳离子镓放射性药物的合成与生物分布：用68Ga进行PET心肌成像的潜在药物。

Nucl Med Biol. 2009 Jan;36(1):39-45. doi: 10.1016/j.nucmedbio.2008.10.010.

Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?放射性镓标记的DOTA偶联生长抑素类似物是否优于其他放射性金属标记的同类物？

Eur J Nucl Med Mol Imaging. 2007 Jul;34(7):982-93. doi: 10.1007/s00259-006-0317-x. Epub 2007 Jan 16.

本文引用的文献

Evaluation of positron emission tomography imaging using [68Ga]-DOTA-D Phe(1)-Tyr(3)-Octreotide in comparison to [111In]-DTPAOC SPECT. First results in patients with neuroendocrine tumors.使用[68Ga]-DOTA-D Phe(1)-Tyr(3)-奥曲肽的正电子发射断层扫描成像与[111In]-DTPA-奥曲肽单光子发射计算机断层扫描的比较评估。神经内分泌肿瘤患者的初步结果。

Mol Imaging Biol. 2003 Jan-Feb;5(1):42-8. doi: 10.1016/s1536-1632(03)00038-6.

Eur J Nucl Med. 2001 Dec;28(12):1751-7. doi: 10.1007/s002590100639. Epub 2001 Oct 31.

PET imaging of somatostatin receptors using [68GA]DOTA-D-Phe1-Tyr3-octreotide: first results in patients with meningiomas.使用[68GA]DOTA-D-苯丙氨酸1-酪氨酸3-奥曲肽对生长抑素受体进行PET成像：脑膜瘤患者的初步结果

J Nucl Med. 2001 Jul;42(7):1053-6.

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Exceptional increase in somatostatin receptor expression in pancreatic neuroendocrine tumour, visualised with (68)Ga-DOTATOC PET.

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