[固定化人工色谱法与正辛醇/缓冲液体系亲脂性的比较研究]
[Comparative study of lipophilicity from immobilized artificial chromatography and n-octanol/buffer systems].
作者信息
Sun Jin, Cheng Gang, He Zhong-gui, Wang Shu-jun
机构信息
Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Yao Xue Xue Bao. 2003 Oct;38(10):791-4.
AIM
To compare lipophilicity measuring scale stemmed from immobilized artificial membrane chromatography and n-octanol/buffer systems.
METHODS
A test set consisted of 27 structurally diverse compounds. The lipophilicity of these were evaluated by both immobilized artificial membrane chromatography (IAMC) and n-octanol/buffer systems, which were expressed as lg kIAM and lg DO/W,7.4, respectively.
RESULTS
With regard to each individual group, good correlation coefficient (r2) over 0.81 was obtained (0.82 for acid; 0.88 for neutral, 0.81 for base and 0.92 for ampholyte, respectively). However, a smaller r2 (0.62) was acquired for all compounds studied than that of each individual group.
CONCLUSION
IAMC and n-octanol/buffer systems were shown to be different in lipophilicity.
目的
比较源自固定化人工膜色谱法和正辛醇/缓冲液系统的亲脂性测量尺度。
方法
一个测试集由27种结构各异的化合物组成。通过固定化人工膜色谱法（IAMC）和正辛醇/缓冲液系统对这些化合物的亲脂性进行评估，分别表示为lg kIAM和lg DO/W,7.4。
结果
就每个单独的组而言，获得了大于0.81的良好相关系数（r2）（酸类为0.82；中性为0.88，碱类为0.81，两性电解质为0.92）。然而，所研究的所有化合物的r2（0.62）比每个单独组的r2小。
结论
结果表明，IAMC和正辛醇/缓冲液系统在亲脂性方面存在差异。
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