胼胝体发育不全相关的脑异常及临床发现
[Associated brain anomalies and clinical findings in corpus callosum dysgenesis].
作者信息
Alkan Alpay, Kutlu Ramazan, Baysal Tamer, Siğirci Ahmet, Altinok Tayfun, Orkan Ismet, Hallaç Tarik, Saraç Kaya
机构信息
Inönü Universitesi Tip Fakültesi, Turgut Ozal Tip Merkezi, Radyodiagnostik Anabilim Dali, Malatya.
出版信息
Tani Girisim Radyol. 2003 Dec;9(4):411-7.
PURPOSE
The aim of this study was to evaluate the relationship between the types of the corpus callosum dysgenesis, the associated brain anomalies and clinical findings.
MATERIALS AND METHODS
We analyzed the MR imaging findings in 169 patients with callosal dysgenesis. Corpus callosum dysgenesis was categorized into agenesis, hypogenesis and hypoplasia. The associated brain anomalies and clinical findings were evaluated.
RESULTS
Associated brain anomalies were observed in 148 patients (87.5%). Twenty-one patients (12.4%) had isolated corpus callosum dysgenesis. Dysgenesis included agenesis in 22 (%13), hypogenesis in 46 (27.2%), and hypoplasia in 101 (59.7%) patients. The clinical findings were most commonly observed in patients with hypoplasia.
CONCLUSION
The presence of corpus callosum dysgenesis is a strong indication of possible associated brain anomalies. Corpus callosum dysgenesis and associated brain anomalies should be investigated in children with developmental delay, seizures and microcephaly.
目的
本研究旨在评估胼胝体发育不全的类型、相关脑异常与临床发现之间的关系。
材料与方法
我们分析了169例胼胝体发育不全患者的磁共振成像结果。胼胝体发育不全分为发育不全、发育不良和发育不全。评估了相关的脑异常和临床发现。
结果
148例患者（87.5%）观察到相关脑异常。21例患者（12.4%）有孤立性胼胝体发育不全。发育不全包括22例（13%）发育不全、46例（27.2%）发育不良和101例（59.7%）发育不全患者。临床发现最常见于发育不全患者。
结论
胼胝体发育不全的存在强烈提示可能存在相关脑异常。对于发育迟缓、癫痫和小头畸形的儿童，应调查胼胝体发育不全和相关脑异常。
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