Zeng Shao-ying, Yang Ping-zhen, Shi Ji-jun, Qu Xi, Wang Hui-shen, Li Yu-fen
Department of Pediatrics, Guangdong Cardiovascular Disease Institute, Guangzhou 510100, China.
Zhonghua Er Ke Za Zhi. 2003 Oct;41(10):732-4.
In children with congenital heart diseases who have undergone surgical interventions, postoperative arrhythmias frequently complicate the clinical course. "Incisional" atrial tachycardia or flutter is one of the most common forms of postoperative arrhythmias in these patients and can lead to significant morbidity and even mortality. The aim of this study was to investigate how to use antiarrhythmic drugs and the CARTO system to treat these cases.
There were 12 patients with "incisional" atrial tachycardia or flutter complicating surgery for congenital heart diseases in this study (3 patients with correction of tetrology of Fallot, 3 with atrial septal defect repair, 2 with ventricular septal defect repair, 1 with switch, 1 with repair of Ebstein's anomaly, 1 with total anomalous pulmonary venous drainage, and 1 with atrial septal closure with the Amplatzer septal occlusion). Patients whose body weight was less than 10 kg or those who did not wish to accept ablation were treated with antiarrhythmic drugs, including digitoxin, propranolol, metoprolol and cordarone. CARTO system was used to map 6 patients whose body weight was more than 10 kg and who agreed with accepting ablation for atrial tachycardia and flutter. Radio-frequency ablation was performed in these 6 cases including two cases of "incisional" atrial tachycardia and 4 of atrial flutter.
(1) The antiarrhythmic drug was successful in 6 patients with "incisional" atrial tachycardia. (2) Six patients including 2 children with "incisional" atrial tachycardia and 4 children with atrial flutter were successfully ablated. But one case of "incisional" atrial tachycardia relapsed after 3 months of ablation. This case, however, was successfully ablated again later. No further relapse was observed during the 2 - 24 months of follow-up.
Ablation of "incisional" atrial tachycardia and flutter is the first choice to treat the patients whose body weight is more than 10 kg and those who agree with accepting ablation by CARTO system. Drug therapy of "incisional" atrial tachycardia and flutter is palliative and it is the only selection to treat the patients whose body weight is less than 10 kg or those who do not wish to accept ablation procedure.
在接受手术干预的先天性心脏病患儿中,术后心律失常常常使临床病程复杂化。“切口性”房性心动过速或心房扑动是这些患者术后心律失常最常见的形式之一,可导致显著的发病率甚至死亡率。本研究的目的是探讨如何使用抗心律失常药物和CARTO系统来治疗这些病例。
本研究中有12例先天性心脏病手术并发“切口性”房性心动过速或心房扑动的患者(3例法洛四联症矫正术患者,3例房间隔缺损修补术患者,2例室间隔缺损修补术患者,1例调转术患者,1例埃布斯坦畸形修补术患者,1例完全性肺静脉异位引流患者,1例使用Amplatzer房间隔封堵器进行房间隔闭合术患者)。体重小于10kg的患者或不愿接受消融治疗的患者采用抗心律失常药物治疗,包括地高辛、普萘洛尔、美托洛尔和可达龙。对6例体重超过10kg且同意接受房性心动过速和心房扑动消融治疗的患者使用CARTO系统进行标测。对这6例患者进行了射频消融,其中包括2例“切口性”房性心动过速和4例心房扑动。
(1)抗心律失常药物治疗6例“切口性”房性心动过速患者取得成功。(2)6例患者成功消融,其中包括2例“切口性”房性心动过速患儿和4例心房扑动患儿。但1例“切口性”房性心动过速患者在消融3个月后复发。不过,该病例后来再次成功消融。在2至24个月的随访期间未观察到进一步复发。
对于体重超过10kg且同意接受CARTO系统消融治疗的患者,“切口性”房性心动过速和心房扑动的消融是首选治疗方法。“切口性”房性心动过速和心房扑动的药物治疗是姑息性的,对于体重小于10kg或不愿接受消融手术的患者是唯一的选择。