Mdm2 对 p53 的调控：命运取决于数量。

Regulation of p53 by Mdm2: fate is in the numbers.

作者信息

Shmueli Ayelet, Oren Moshe

机构信息

Department of Molecular Cell Biology, The Weizmann Institute of Science, POB 26, 76100 Rehovot, Israel.

出版信息

Mol Cell. 2004 Jan 16;13(1):4-5. doi: 10.1016/s1097-2765(03)00529-x.

DOI:10.1016/s1097-2765(03)00529-x

PMID:14731389

Abstract

The p53 tumor suppressor protein is normally restrained by the Mdm2 oncoprotein, which promotes p53 ubiquitination. In a recent issue of Science, report that p53 may face two alternative fates, depending on Mdm2 levels: high Mdm2 drives p53 polyubiquitination and degradation within the cell nucleus, whereas low Mdm2 promotes p53 monoubiquitination and nuclear exclusion.

摘要

p53肿瘤抑制蛋白通常受Mdm2癌蛋白的抑制，Mdm2可促进p53的泛素化。在最近一期的《科学》杂志上，有报道称p53可能面临两种不同的命运，这取决于Mdm2的水平：高Mdm2水平会促使p53在细胞核内发生多聚泛素化并降解，而低Mdm2水平则会促进p53的单泛素化并使其被排除在细胞核外。