DNA片段化在细胞凋亡中的作用。
The role of DNA fragmentation in apoptosis.
作者信息
Bortner C D, Oldenburg N B, Cidlowski J A
机构信息
Dept of Physiology and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Trends Cell Biol. 1995 Jan;5(1):21-6. doi: 10.1016/s0962-8924(00)88932-1.
The formation of distinct DNA fragments of oligonucleosomal size (180-200 bp lengths) is a biochemical hallmark of apoptosis in many cells. Recent observations also suggest large DNA fragments and even single-strand cleavage events occur during cell death. These observations have raised many questions. What are the types of DNA cleavage observed during apoptosis? What are the nucleases involved? And what is the role of these nucleolytic events in apoptosis?
寡核小体大小（长度为180 - 200碱基对）的独特DNA片段的形成是许多细胞凋亡的生化标志。最近的观察结果还表明，在细胞死亡过程中会出现大片段DNA甚至单链切割事件。这些观察结果引发了许多问题。在凋亡过程中观察到的DNA切割类型有哪些？涉及哪些核酸酶？这些核酸水解事件在凋亡中的作用是什么？
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