T细胞活化

T-cell activation.

作者信息

Izquierdo M, Cantrell D A

机构信息

The authors are at the Lymphocyte Activation Laboratory, ICRF Laboratories, PO Box 123, Lincoln's, Inn Fields, London, UK WC2A 3PX.

出版信息

Trends Cell Biol. 1992 Sep;2(9):268-71. doi: 10.1016/0962-8924(92)90199-w.

DOI:10.1016/0962-8924(92)90199-w

PMID:14731519

Abstract

Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca(2+) levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21(ras) acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.

摘要

T淋巴细胞的激活会导致细胞内立即发生生化变化，包括胞质Ca(2+)水平升高、蛋白激酶C（PKC）的激活以及蛋白酪氨酸激酶（PTK）的调节。本文综述了T细胞中PKC和PTK下游信号传导步骤研究的最新进展。文中提出了一个模型，其中GTP结合蛋白p21(ras)作为由T细胞抗原受体控制的信号转导途径的整合者。