CD3和CD4基因多态性与胰岛素依赖型糖尿病（IDDM）之间可能存在的关联。
Possible association of CD3 and CD4 polymorphisms with insulin-dependent diabetes mellitus (IDDM).
作者信息
Ghabanbasani M Z, Buyse I, Legius E, Decorte R, Marynen P, Bouillon R, Cassiman J J
机构信息
Centre for Human Genetics, University of Leuven, Belgium.
出版信息
Clin Exp Immunol. 1994 Sep;97(3):517-21. doi: 10.1111/j.1365-2249.1994.tb06119.x.
Population and family studies show that predisposition to type I diabetes (IDDM) is multifactorial, and that polymorphisms in the MHC region contribute substantially to the susceptibility to IDDM. In the present study the association of polymorphisms in the CD4 and the delta subunit of CD3 with IDDM were examined in a Belgian population. We observed that the frequency of the CD A4/A4 genotype and of the CD3 91 allele were significantly increased P = 0.0077) and decreased (P = 3.8 x 10(-5), respectively, in IDDM compared with controls. These results therefore suggest that CD4, CD3 or neighbouring genes might contribute to IDDM susceptibility. These results are, however, preliminary and cannot be considered as established until re-tested in a new population.
人群和家族研究表明，I型糖尿病（IDDM）的易感性是多因素的，并且MHC区域的多态性在很大程度上导致了对IDDM的易感性。在本研究中，我们在比利时人群中检测了CD4和CD3δ亚基的多态性与IDDM的相关性。我们观察到，与对照组相比，IDDM患者中CD4 A4/A4基因型的频率显著增加（P = 0.0077），而CD3 91等位基因的频率显著降低（P = 3.8 x 10-5）。因此，这些结果表明CD4、CD3或其邻近基因可能与IDDM易感性有关。然而，这些结果是初步的，在新人群中重新测试之前不能视为定论。
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