亲环蛋白：参与细胞内折叠的新蛋白质家族。

Cyclophilins: a new family of proteins involved in intracellular folding.

作者信息

Stamnes M A, Rutherford S L, Zuker C S

机构信息

Howard Hughes Medical Institute and Departments of Biology and Neuroscience, University of California at San Diego, La Jolla, CA 92093-0649, USA.

出版信息

Trends Cell Biol. 1992 Sep;2(9):272-6. doi: 10.1016/0962-8924(92)90200-7.

DOI:10.1016/0962-8924(92)90200-7

PMID:14731520

Abstract

Proteins of the cyclophilin family display two intriguing properties. On the one hand, they are the intracellular receptors for the immunosuppressive drug cyclosporin A (CsA); on the other hand, they function in vitro as enzymes that catalyse slow steps in protein folding. A dissection of the role of CsA in mediating immunosuppression, together with recent studies on the biology of cyclophilins in the absence of this ligand, is providing fundamental insight into the cellular function of this protein family.

摘要

亲环蛋白家族的蛋白质具有两个有趣的特性。一方面，它们是免疫抑制药物环孢素A（CsA）的细胞内受体；另一方面，它们在体外作为酶发挥作用，催化蛋白质折叠过程中的缓慢步骤。对CsA介导免疫抑制作用的剖析，以及最近在没有这种配体的情况下对亲环蛋白生物学的研究，正在为深入了解这个蛋白质家族的细胞功能提供基础。