Lin H Y, Lodish H F
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Trends Cell Biol. 1993 Jan;3(1):14-9. doi: 10.1016/0962-8924(93)90195-7.
Members of the transforming growth factor beta (TGF-beta) superfamily of peptide growth factors have profound effects on the growth and differentiation of many cell types. Insights into the poorly understood mechanisms of action of these ligands have come from the recent molecular cloning of two types of high-affinity receptors - type II and type III - for TGF-beta superfamily members. The cell surface expression of the type III receptor, a membrane-bound proteoglycan, appears to modulate the binding of ligand to the type II receptor, which is a transmembrane serine/threonine kinase. These results provide evidence for interactions between different receptor types, and suggest that serine/threonine phosphorylation is an important element in TGF-beta-induced signalling.
肽生长因子转化生长因子β（TGF-β）超家族的成员对多种细胞类型的生长和分化具有深远影响。对这些配体作用机制的深入了解来自于最近对TGF-β超家族成员的两种高亲和力受体——II型和III型受体的分子克隆。III型受体是一种膜结合蛋白聚糖，其在细胞表面的表达似乎可调节配体与II型受体的结合，II型受体是一种跨膜丝氨酸/苏氨酸激酶。这些结果为不同受体类型之间的相互作用提供了证据，并表明丝氨酸/苏氨酸磷酸化是TGF-β诱导信号传导中的一个重要因素。
