Lin H Y, Moustakas A
Program in Membrane Biology, Massachusetts General Hospital, Boston 02114.
Cell Mol Biol (Noisy-le-grand). 1994 May;40(3):337-49.
The transforming growth factor beta (TGF-beta) superfamily of dimeric polypeptide growth factors regulate cell growth and differentiation and play important roles in embryonic development and the immune response. The molecular cloning of three types of high affinity cell-surface receptors (type I, type II and type III) for these growth factors provide insights into their poorly understood mechanisms of action. Here we focus on the structure of these receptors and on the complex interactions which occur between different receptors that are necessary for ligand-induced signal transduction. The type I and type II receptors are both related transmembrane serine/threonine kinase receptors which may hetero-oligomerize to transduce proper signals. The type III receptor modulates the binding of ligands to the signaling complex of type I and type II receptors. These findings suggest that serine/threonine phosphorylation and heteromeric receptor interactions are important elements of TGF-beta induced signaling.
二聚体多肽生长因子的转化生长因子β（TGF-β）超家族调节细胞生长和分化，并在胚胎发育和免疫反应中发挥重要作用。这些生长因子的三种高亲和力细胞表面受体（I型、II型和III型）的分子克隆为其作用机制的深入理解提供了线索，而这些机制此前了解甚少。在这里，我们重点关注这些受体的结构以及不同受体之间发生的复杂相互作用，这些相互作用是配体诱导信号转导所必需的。I型和II型受体都是相关的跨膜丝氨酸/苏氨酸激酶受体，它们可能异源寡聚化以转导适当的信号。III型受体调节配体与I型和II型受体信号复合物的结合。这些发现表明，丝氨酸/苏氨酸磷酸化和异源受体相互作用是TGF-β诱导信号转导的重要元素。
