Mayer-Jaekel R E, Hemmings B A
Arbeitsgruppe für Zellbiologie-Tumorbiologie, Universität Konstanz, 78434 Konstanz, Germany.
Trends Cell Biol. 1994 Aug;4(8):287-91. doi: 10.1016/0962-8924(94)90219-4.
Protein phosphorylation is probably the major regulatory mechanism employed by eukaryotic cells. Much work has been devoted to the role of protein kinases and their modulation by hormones, growth factors and neurotransmitters. It is now appreciated that protein phosphatases are also key players in actively regulating many cellular processes. In this article we discuss recent advances in our understanding of the function of protein phosphatase 2A, one of the major serine/threonine-specific protein phosphatases.
蛋白质磷酸化可能是真核细胞采用的主要调节机制。许多工作致力于研究蛋白激酶的作用及其受激素、生长因子和神经递质的调节。现在人们认识到，蛋白磷酸酶在积极调节许多细胞过程中也是关键参与者。在本文中，我们讨论了我们对主要的丝氨酸/苏氨酸特异性蛋白磷酸酶之一——蛋白磷酸酶2A功能的理解的最新进展。
