Sandoval I V, Bakke O
Centro de Biologia Molecular, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Trends Cell Biol. 1994 Aug;4(8):292-7. doi: 10.1016/0962-8924(94)90220-8.
The pathways involved in targeting membrane proteins to lysosomes are extraordinarily complex. Newly synthesized proteins in the ER are transported to the Golgi complex, and upon arrival at the trans Golgi network (TGN) are targeted either directly to endosomes, or first to the cell surface from where they can be rapidly internalized into the endocytic pathway for delivery to lysosomes. The routes to endosomes are specified by sorting motifs in the cytoplasmic tails of the proteins that are recognized at the TGN or plasma membrane. The molecular details of these processes are just emerging.
将膜蛋白靶向溶酶体的途径极其复杂。内质网中新合成的蛋白质被转运到高尔基体复合体，到达反式高尔基体网络（TGN）后，要么直接靶向内体，要么先到达细胞表面，然后从那里迅速内化进入内吞途径，以便输送到溶酶体。到达内体的途径由蛋白质细胞质尾巴中的分选基序决定，这些分选基序在TGN或质膜上被识别。这些过程的分子细节才刚刚开始显现。
