Maurelli A T
Department of Microbiology and Immunology, Uniformed Armed Services University of the Health Sciences, Bethesda, MD 2014-4799, USA.
Trends Cell Biol. 1994 Jul;4(7):240-2. doi: 10.1016/0962-8924(94)90116-3.
A number of Gram-negative bacterial pathogens secrete 'virulence determinants' directly into the extracellular medium, where they interact with host cells to promote disease. The study of the secretion machinery used by these organisms to transport specific virulence determinants out to the cell surface and beyond is of growing importance in the field of bacterial pathogenesis. Elements of the secretion machinery are shared by several pathogens. These homologous elements may lead to a better understanding of how the machinery works, but the unique elements will tell us more about what distinguishes one bacterial pathogen from another.
许多革兰氏阴性细菌病原体直接将“毒力决定因素”分泌到细胞外介质中，在那里它们与宿主细胞相互作用以引发疾病。研究这些生物体用于将特定毒力决定因素转运到细胞表面及细胞外的分泌机制，在细菌致病机制领域的重要性日益增加。几种病原体共享分泌机制的元件。这些同源元件可能有助于更好地理解该机制的工作方式，但独特的元件将让我们更多地了解一种细菌病原体与另一种细菌病原体的区别所在。
