Pathogenesis: New Insights through Advanced Methodologies.

is a genus of Gram-negative enteropathogens that have long been, and continue to be, an important public health concern worldwide. Over the past several decades, spp. have also served as model pathogens in the study of bacterial pathogenesis, and has become one of the best-studied pathogens on a molecular, cellular, and tissue level. In the arms race between and the host immune system, has developed highly sophisticated mechanisms to subvert host cell processes in order to promote infection, escape immune detection, and prevent bacterial clearance. Here, we give an overview of pathogenesis while highlighting innovative techniques and methods whose application has significantly advanced our understanding of pathogenesis in recent years.