Fas/APO-1受体及其致命配体。
The Fas/APO-1 receptor and its deadly ligand.
作者信息
Schulze-Osthoff K
机构信息
Institute for Biochemistry, Albert-Ludwigs-University, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany.
出版信息
Trends Cell Biol. 1994 Dec;4(12):421-6. doi: 10.1016/0962-8924(94)90102-3.
PMID:14731690
Abstract
The cell surface receptor Fas/APO-1 and its ligand have recently been identified as important mediators of apoptosis. Both molecules are crucial for the maintenance of a sound immune system, and when defective they give rise to severe autoimmune disorders. Understanding the mechanism and regulation of Fas/APO-1-triggered cell death promises important insights for the pathogenesis of AIDS, cancer and autoimmune diseases.
摘要
细胞表面受体Fas/APO-1及其配体最近被确定为细胞凋亡的重要介质。这两种分子对于维持健全的免疫系统至关重要，一旦有缺陷，就会引发严重的自身免疫性疾病。了解Fas/APO-1触发的细胞死亡机制和调控有望为艾滋病、癌症及自身免疫性疾病的发病机理提供重要见解。
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