离子霉素和锌对麻风病患者外周血单个核细胞（PBMC）凋亡的抑制作用。

Inhibition of apoptosis by ionomycin and zinc in peripheral blood mononuclear cells (PBMC) of leprosy patients.

作者信息

Gupta A, Sharma V K, Vohra H, Ganguly N K

机构信息

Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Clin Exp Immunol. 1999 Jul;117(1):56-62. doi: 10.1046/j.1365-2249.1999.00908.x.

DOI:10.1046/j.1365-2249.1999.00908.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1905487/

Abstract

PBMC from tuberculoid (BT/TT) and lepromatous leprosy (BL/LL) leprosy patients showed spontaneous apoptosis when cultured in the absence of mitogen for 24 h, which was inhibited by anti-tumour necrosis factor-alpha (TNF-alpha) antibodies. Apoptosis was also inhibited by ionomycin and zinc, which also increased IL-2 and decreased TNF-alpha production. The increase in IL-2 production suggests a mechanism whereby dietary supplements with zinc might alter the cell-mediated immunity response in leprosy patients.

摘要

来自结核样型（BT/TT）和瘤型麻风（BL/LL）患者的外周血单核细胞（PBMC）在无丝裂原培养24小时时显示出自发凋亡，这被抗肿瘤坏死因子-α（TNF-α）抗体所抑制。离子霉素和锌也抑制了凋亡，它们还增加了白细胞介素-2（IL-2）的产生并减少了TNF-α的产生。IL-2产生的增加提示了一种机制，即锌的膳食补充剂可能改变麻风患者的细胞介导免疫反应。

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本文引用的文献

1

The Fas/APO-1 receptor and its deadly ligand.

Trends Cell Biol. 1994 Dec;4(12):421-6. doi: 10.1016/0962-8924(94)90102-3.

2

Signal transduction pathways to apoptosis.

Trends Cell Biol. 1994 Oct;4(10):370-5. doi: 10.1016/0962-8924(94)90087-6.

3

The immunobiology of zinc.

Immunol Today. 1997 Nov;18(11):519-21. doi: 10.1016/s0167-5699(97)01146-8.

4

Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype.

J Immunol. 1997 Aug 1;159(3):1160-8.

5

The management of erythema nodosum leprosum: current and future options.

Lepr Rev. 1996 Dec;67(4):253-9. doi: 10.5935/0305-7518.19960026.

6

Serum zinc, copper, magnesium, proteins and superoxide dismutase in leprosy patients on multidrug therapy--a follow-up study.

Indian J Lepr. 1996 Oct-Dec;68(4):325-33.

7

Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy.

J Exp Med. 1996 Jul 1;184(1):159-64. doi: 10.1084/jem.184.1.159.

8

Models of T cell anergy: is there a common molecular mechanism?

J Exp Med. 1996 Jul 1;184(1):1-8. doi: 10.1084/jem.184.1.1.

9

Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression.

Eur J Immunol. 1996 Feb;26(2):294-9. doi: 10.1002/eji.1830260204.

10

Detection of intracellular cytokines by flow cytometry.

J Immunol Methods. 1993 Feb 26;159(1-2):197-207. doi: 10.1016/0022-1759(93)90158-4.

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