Mx蛋白：具有抗病毒活性的GTP酶。

Mx proteins: GTPases with antiviral activity.

作者信息

Staeheli P, Pitossi F, Pavlovic J

机构信息

Department of Virology, Institute of Microbiology and Hygiene, University of Freiburg, Germany.

出版信息

Trends Cell Biol. 1993 Aug;3(8):268-72. doi: 10.1016/0962-8924(93)90055-6.

DOI:10.1016/0962-8924(93)90055-6

PMID:14731745

Abstract

Mx proteins are synthesized in interferon-treated vertebrate cells. They have attracted much attention because some of them can block the multiplication of influenza A virus and certain other negative-stranded RNA viruses. Recently, Mx proteins have been shown to be GTPases with significant homology to dynamins and yeast VPS1, enzymes involved in intracellular protein trafficking. Several biochemical properties of dynamin and VPS1 are similar to those of Mx, promoting new speculation about how Mx proteins might interfere with virus multiplication.

摘要

Mx蛋白在经干扰素处理的脊椎动物细胞中合成。它们备受关注，因为其中一些蛋白能够阻断甲型流感病毒和某些其他负链RNA病毒的增殖。最近，Mx蛋白已被证明是与发动蛋白和酵母VPS1具有显著同源性的GTP酶，这些酶参与细胞内蛋白质运输。发动蛋白和VPS1的一些生化特性与Mx蛋白相似，这引发了关于Mx蛋白如何干扰病毒增殖的新推测。