有丝分裂纺锤体极分离

Mitotic spindle pole separation.

作者信息

Saunders W S

机构信息

Department of Biology, Mudd Hall, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218-2685, USA.

出版信息

Trends Cell Biol. 1993 Dec;3(12):432-7. doi: 10.1016/0962-8924(93)90032-v.

DOI:10.1016/0962-8924(93)90032-v

PMID:14731889

Abstract

Eukaryotic cells utilize a microtubular spindle to segregate chromosomes during mitosis. Chromosome segregation requires the timely separation of the mitotic spindle poles to which the chromosomes are attached. Recent studies at the molecular and cellular levels have provided new insights into the mechanism and regulation of this process. On the one hand, the process now seems more complex, as redundant mechanisms apparently overlap in function during cell division. On the other hand, some of these processes may be acting continuously during the various stages of spindle pole separation, suggesting an underlying simplicity.

摘要

真核细胞在有丝分裂期间利用微管纺锤体来分离染色体。染色体分离需要及时分离与染色体相连的有丝分裂纺锤体两极。最近在分子和细胞水平上的研究为这一过程的机制和调控提供了新的见解。一方面，这个过程现在看起来更加复杂，因为在细胞分裂过程中，冗余机制在功能上显然存在重叠。另一方面，其中一些过程可能在纺锤体极分离的各个阶段持续起作用，这表明其潜在的简单性。