肿瘤侵袭：细胞黏附和运动的影响

Tumour invasion: effects of cell adhesion and motility.

作者信息

Van Roy F, Mareel M

机构信息

Laboratory of Molecular Biology, University of Ghent, Ledeganckstraat 35, B-9000 Ghent, Belgium.

出版信息

Trends Cell Biol. 1992 Jun;2(6):163-9. doi: 10.1016/0962-8924(92)90035-l.

DOI:10.1016/0962-8924(92)90035-l

PMID:14731985

Abstract

Metastasis is the major cause of failure in cancer therapy. Recent studies of the molecular cell biology of the metastatic process have provided new insights into the mechanisms of cell-cell adhesion, cell-substrate adhesion and cell motility that underly invasion by tumour cells. In this review, Van Roy and Mareel discuss the role of proteins with invasion-promoting and invasion-suppressing functions in metastasis.

摘要

转移是癌症治疗失败的主要原因。最近对转移过程分子细胞生物学的研究为肿瘤细胞侵袭所依赖的细胞间黏附、细胞与基质黏附以及细胞运动机制提供了新的见解。在这篇综述中，范·罗伊和马雷尔讨论了具有促进侵袭和抑制侵袭功能的蛋白质在转移中的作用。