Kraehenbuhl J P, Neutra M R
Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, Switzerland.
Trends Cell Biol. 1992 Jun;2(6):170-4. doi: 10.1016/0962-8924(92)90036-m.
In this second article on mucosal defence and transepithelial transport, Jean-Pierre Kraehenbuhl and Marian Neutra discuss the part played by a special class of antibody, polymeric IgA, in the protection of mucosal surfaces lining the digestive, respiratory and genital tracts, and the implications for mucosal vaccines. Polymeric IgA crosslinks luminal antigens or pathogens, thus preventing their interaction with epithelial cells. Following stimulation by antigen in the organized mucosal lymphoid tissue, effector B lymphocytes enter the circulation and migrate to distant mucosal or glandular sites, where they differentiate into polymeric-IgA-producing plasma cells. These antibodies reach the environment by transport across the epithelial cells of mucosal and glandular tissues.
在这篇关于黏膜防御和跨上皮运输的第二篇文章中，让 - 皮埃尔·克雷亨布尔和玛丽安·纽特拉讨论了一类特殊抗体——聚合免疫球蛋白A（polymeric IgA）在保护消化、呼吸和生殖道黏膜表面中所起的作用，以及对黏膜疫苗的影响。聚合免疫球蛋白A使腔内抗原或病原体交联，从而阻止它们与上皮细胞相互作用。在有组织的黏膜淋巴组织中受到抗原刺激后，效应B淋巴细胞进入循环并迁移到远处的黏膜或腺体部位，在那里它们分化为产生聚合免疫球蛋白A的浆细胞。这些抗体通过跨黏膜和腺组织的上皮细胞运输到达相应环境。
