Solari R, Kraehenbuhl J P
Institute of Biochemistry and Swiss Institute for Experimental Cancer Research, Université de Lausanne, CH-1066 Epalinges, Switzerland.
Immunol Today. 1985 Jan;6(1):17-20. doi: 10.1016/0167-5699(85)90163-X.
How animals protect their mucosal surfaces from environmental pathogens has been of much recent interest. Elucidation of the defence mechanisms involved led to the concept of a common mucosal immune system, characterized by an intimate relationship between mucosal epithelia and migrating populations of IgA-producing B cells(1). However, in order to protect mucosal surfaces fom environmental antigens the dimeric IgA antibodies must somehow be transported across the mucous or exocrine gland epithelia and released into the external secretions. In this article R. Solari and J.-P. Kraehenbuhl show how the secretory component may facilitate this movement and also discuss its possible biosynthesis and processing.
动物如何保护其黏膜表面免受环境病原体侵害，这一问题近来备受关注。对相关防御机制的阐释催生了共同黏膜免疫系统的概念，其特点是黏膜上皮与产生IgA的B细胞迁移群体之间存在密切关系(1)。然而，为了保护黏膜表面免受环境抗原的侵害，二聚体IgA抗体必须以某种方式穿过黏液或外分泌腺上皮，并释放到外分泌物中。在本文中，R. 索拉里和J.-P. 克雷亨布尔展示了分泌成分如何促进这种转运，并讨论了其可能的生物合成和加工过程。
