Jackson S P
Wellcome/CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, UK.
Trends Cell Biol. 1992 Apr;2(4):104-8. doi: 10.1016/0962-8924(92)90014-e.
The initiation of transcription by RNA polymerase II is controlled by transcription factors. Changes in gene transcription are brought about by regulating the activity of these factors. Phosphorylation of transcription factors as a regulatory mechanism is both rapid and readily reversible. Furthermore, because a transcription factor can be targeted by many protein kinases and phosphatases, phosphorylation can effectively integrate information carried by multiple signal transduction pathways, thus providing opportunities for great versatility and flexibility in gene regulation.
RNA聚合酶II介导的转录起始受转录因子调控。基因转录的变化是通过调节这些因子的活性来实现的。作为一种调控机制，转录因子的磷酸化反应迅速且易于逆转。此外，由于一个转录因子可能会被多种蛋白激酶和磷酸酶作用，磷酸化能够有效地整合多条信号转导途径携带的信息，从而为基因调控提供了广泛的多样性和灵活性。
