小GTP结合蛋白对吞噬细胞呼吸爆发的调节
Regulation of the phagocyte respiratory burst by small GTP-binding proteins.
作者信息
Bokoch G M
机构信息
Depts of Immunology and Cell Biology, The Scripps Research Institute, 10666 N Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Trends Cell Biol. 1995 Mar;5(3):109-13. doi: 10.1016/s0962-8924(00)88960-6.
Abstract
Bacteria phagocytosed by leukocytes are killed and degraded by toxic oxygen metabolites produced in the phagosome via an NADPH oxidase. NADPH oxidase activity is regulated by small GTP-binding proteins in response to phagocytic stimuli. In this review, Gary Bokoch focuses on the role of Rac in regulating this important phagocytic process.
摘要
被白细胞吞噬的细菌会被吞噬小体中通过NADPH氧化酶产生的有毒氧代谢产物杀死并降解。NADPH氧化酶活性受小GTP结合蛋白调控，以响应吞噬刺激。在这篇综述中，加里·博科奇重点论述了Rac在调节这一重要吞噬过程中的作用。
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