Isberg R R, Van Nhieu G T
Howard Hughes Medical Institute and Dept of Microbiology and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA.
Trends Cell Biol. 1995 Mar;5(3):120-4. doi: 10.1016/s0962-8924(00)88962-x.
Many pathogenic bacterial species produce factors that promote their internalization by host cells. The crucial components for uptake of one such pathogen, Yersinia pseudotuberculosis, have been identified. Efficient uptake of this microorganism requires tight binding of the bacterial invasin protein to integrins on the cell surface. Internalization also involves coordination of signals responsible for cytoskeletal rearrangements and those involved in receptor-mediated endocytosis. A start is being made to define the proteins that are required for efficient completion of the internalization process.
许多致病细菌物种会产生促进其被宿主细胞内化的因子。一种这样的病原体——假结核耶尔森菌摄取的关键成分已被确定。这种微生物的有效摄取需要细菌侵袭蛋白与细胞表面的整合素紧密结合。内化还涉及负责细胞骨架重排的信号与受体介导的内吞作用相关信号的协调。人们已开始确定有效完成内化过程所需的蛋白质。
