Ziyaie D, Hupp T R, Thompson A M
Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Breast. 2000 Oct;9(5):239-46. doi: 10.1054/brst.2000.0199.
p53 mutation is the most common genetic abnormality found so far in human cancer, and in breast cancer p53 mutation/alteration is seen in up to 50% of primary carcinomas. Together with the increasing knowledge of the characteristics and understanding of the role of p53 over the last two decades, attention in recent years has been focused on how this knowledge can be used in clinical settings for patient care and management in terms of analyzing p53 as a potential marker for studying the relationship between p53 expression and tumour development, progression and outcome; and designing alternative treatment strategies specifically aimed at restoring normal p53 function.
p53突变是迄今为止在人类癌症中发现的最常见的基因异常，在乳腺癌中，高达50%的原发性癌可见p53突变/改变。在过去二十年里，随着对p53特征的了解不断增加以及对其作用的认识不断深入，近年来人们的注意力集中在如何将这些知识应用于临床，用于患者护理和管理，具体包括分析p53作为研究p53表达与肿瘤发生、发展及转归之间关系的潜在标志物；以及设计旨在恢复正常p53功能的替代治疗策略。
