Bramlage P, Wittchen H U, Pittrow D, Dikow R, Kirch W, Lehnert H, Ritz E
Institut für Klinische Psychologie und Psychotherapie, TU Dresden.
Fortschr Med Orig. 2003 Feb 27;121 Suppl 1:33-8.
Microalbuminuria has been widely appreciated in recent years to be a valuable risk marker for an increased cardiovascular disease morbidity and mortality. Thus guidelines for the treatment of type-2-diabetes in Germany and the US recommend an annual screening as soon as the diagnosis of diabetes is established and a quarterly control when microalbuminuria is present. While nationally representative epidemiologic data from the US have been available, data from Germany, especially from the primary care sector are missing. This is especially important in light of the gatekeeper function of the primary care physician. The "Hypertension and Diabetes Risk Screening Study" (HYDRA) has been identifying 37.8% of patients with hypertension and diabetes to have a positive dipstick test for microalbuminuria on the study day while only 12.5% of these are diagnosed by the doctor as having nephropathy. These patients additionally show a high burden of associated comorbidities and thus call for early detection and intervention especially because effective therapy is available. Although screening for microalbuminuria is recommended in the guidelines the value of a routine screening for microalbuminuria in primary care is under recognized.
近年来,微量白蛋白尿已被广泛认为是心血管疾病发病率和死亡率增加的重要风险标志物。因此,德国和美国的2型糖尿病治疗指南建议,一旦确诊糖尿病,应每年进行一次筛查;若存在微量白蛋白尿,则应每季度进行一次检查。虽然美国有全国代表性的流行病学数据,但德国的数据,尤其是来自初级医疗部门的数据却缺失。鉴于初级保健医生的把关作用,这一点尤为重要。“高血压与糖尿病风险筛查研究”(HYDRA)发现,在研究当天,37.8%的高血压和糖尿病患者尿试纸检测微量白蛋白尿呈阳性,而其中只有12.5%被医生诊断为肾病。这些患者还伴有高负担的相关合并症,因此需要早期检测和干预,特别是因为有有效的治疗方法。尽管指南中建议对微量白蛋白尿进行筛查,但初级保健中常规筛查微量白蛋白尿的价值尚未得到充分认识。