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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Pharmacy, University of Sydney, New South Wales, Australia.

Clin Exp Pharmacol Physiol. 1992 Dec;19(12):803-7. doi: 10.1111/j.1440-1681.1992.tb00418.x.

The effect of cimetidine on gallamine-induced neuromuscular paralysis was evaluated in urethane-anaesthetized and mechanically ventilated rats. 2. Intravenous cimetidine (between 3.2 and 100 mg/kg) produced an immediate and sustained potentiation of gallamine-induced neuromuscular paralysis. 3. Intravenous calcium (0.35 mmol/kg) completely reversed the cimetidine-induced potentiation of gallamine's effect. 4. Cimetidine alone did not produce neuromuscular paralysis. 5. Cimetidine did not alter either the serum concentration or the total serum clearance of gallamine. 6. Cimetidine thus potentiates the action of gallamine via a pharmacodynamic and not a pharmacokinetic mechanism.

在乌拉坦麻醉并机械通气的大鼠中评估了西咪替丁对加拉明诱导的神经肌肉麻痹的影响。2. 静脉注射西咪替丁（3.2至100毫克/千克）可立即并持续增强加拉明诱导的神经肌肉麻痹。3. 静脉注射钙（0.35毫摩尔/千克）可完全逆转西咪替丁诱导的加拉明作用增强。4. 单独使用西咪替丁不会产生神经肌肉麻痹。5. 西咪替丁既不改变加拉明的血清浓度，也不改变其血清总清除率。6. 因此，西咪替丁通过药效学而非药代动力学机制增强加拉明的作用。

Department of Pharmacy, University of Sydney, New South Wales, Australia.

Clin Exp Pharmacol Physiol. 1992 Dec;19(12):803-7. doi: 10.1111/j.1440-1681.1992.tb00418.x.

The effect of cimetidine on gallamine-induced neuromuscular paralysis was evaluated in urethane-anaesthetized and mechanically ventilated rats. 2. Intravenous cimetidine (between 3.2 and 100 mg/kg) produced an immediate and sustained potentiation of gallamine-induced neuromuscular paralysis. 3. Intravenous calcium (0.35 mmol/kg) completely reversed the cimetidine-induced potentiation of gallamine's effect. 4. Cimetidine alone did not produce neuromuscular paralysis. 5. Cimetidine did not alter either the serum concentration or the total serum clearance of gallamine. 6. Cimetidine thus potentiates the action of gallamine via a pharmacodynamic and not a pharmacokinetic mechanism.

在乌拉坦麻醉并机械通气的大鼠中评估了西咪替丁对加拉明诱导的神经肌肉麻痹的影响。2. 静脉注射西咪替丁（3.2至100毫克/千克）可立即并持续增强加拉明诱导的神经肌肉麻痹。3. 静脉注射钙（0.35毫摩尔/千克）可完全逆转西咪替丁诱导的加拉明作用增强。4. 单独使用西咪替丁不会产生神经肌肉麻痹。5. 西咪替丁既不改变加拉明的血清浓度，也不改变其血清总清除率。6. 因此，西咪替丁通过药效学而非药代动力学机制增强加拉明的作用。