内皮素对慢性缺氧自发性高血压大鼠的直接肾脏作用

Direct renal effects of endothelin in chronic hypoxic spontaneously hypertensive rats.

Chen C F, Chien C T, Wu M S

Department of Physiology, College of Medicine, National Taiwan University, Taipei.

Clin Exp Pharmacol Physiol. 1992 Dec;19(12):809-13. doi: 10.1111/j.1440-1681.1992.tb00419.x.

Abstract

The direct renal effects of endothelin (ET) were studied in eight chronic hypoxic rats (HA) and eight sea level (SL) spontaneously hypertensive rats (SHR). 2. After 4 weeks of exposure to simulated 5486 m (18,000 ft) hypoxia, all HA rats were in apparently good health, and baseline renal function, except effective renal blood flow, was not significantly different from SL rats. 3. Intrarenal arterial administration of ET (600 ng/kg per h) reduced ipsilateral renal excretion of water, sodium and potassium, glomerular filtration rate and effective renal plasma flow in both SL and HA rats to almost the same extent. 4. Administration of ET antiserum, however, increased the renal excretion of water in HA rats. 5. It is concluded that ET may play a role in the renal regulation of chronic hypoxic SHR.

摘要

在内皮素（ET）对八只慢性低氧大鼠（HA）和八只海平面（SL）自发性高血压大鼠（SHR）的直接肾脏效应进行了研究。2. 在暴露于模拟5486米（18,000英尺）低氧环境4周后，所有HA大鼠健康状况良好，除有效肾血流量外，其基线肾功能与SL大鼠无显著差异。3. 肾内动脉注射ET（每小时600 ng/kg）使SL和HA大鼠同侧肾脏的水、钠和钾排泄量、肾小球滤过率及有效肾血浆流量均降低至几乎相同程度。4. 然而，注射ET抗血清可增加HA大鼠的肾水排泄量。5. 得出结论，ET可能在慢性低氧SHR的肾脏调节中发挥作用。