Bulstrode N W, Bisson M, Jemec B, Pratt A L, McGrouther D A, Grobbelaar A O
From the RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood, HA6 2RN, UK.
J Hand Surg Br. 2004 Feb;29(1):18-21. doi: 10.1016/j.jhsb.2003.08.002.
5-Fluorouracil reduces proliferation rates of fibroblasts, myofibroblast differentiation and contractility of ocular fibroblasts in vitro. This double-blind randomized clinical trial assesses whether intra-operative topical treatment with 5-fluorouracil reduces the recurrence rate after limited excision of Dupuytren's tissue. Patients with two-digit disease were randomized to having 5-fluorouracil (25mg/ml) treatment for 5 minutes on one digit and placebo on the other. Fifteen patients were enrolled with 18 months follow-up. There were no peri-operative complications. Wound healing was not delayed and there was no deterioration in the flexion deformity of the 5-fluorouracil treated digits. Patients were subsequently assessed by joint angle measurement at 3, 6, 12 and 18 months. There was no significant difference between control and 5-fluorouracil treated digits.
5-氟尿嘧啶可降低体外培养的成纤维细胞的增殖率、肌成纤维细胞分化以及眼部成纤维细胞的收缩性。这项双盲随机临床试验评估术中局部应用5-氟尿嘧啶是否能降低Dupuytren组织有限切除术后的复发率。患有两位数疾病的患者被随机分为一组手指接受5-氟尿嘧啶（25mg/ml）治疗5分钟，另一组手指接受安慰剂治疗。共招募了15名患者，并进行了18个月的随访。未发生围手术期并发症。伤口愈合未延迟，5-氟尿嘧啶治疗手指的屈曲畸形也未恶化。随后在3、6、12和18个月时通过关节角度测量对患者进行评估。对照组和5-氟尿嘧啶治疗组的手指之间没有显著差异。
