Millet Anne C M, Ewbank Jonathan J
Institut National de la Sante et de la Recherche Medicale/Centre National pour la Recherche Scientifique /Université de la Méditerranée, 13288 Cedex 9 Marseille, France.
Curr Opin Immunol. 2004 Feb;16(1):4-9. doi: 10.1016/j.coi.2003.11.005.
Until very recently it was not known whether the invertebrate Caenorhabditis elegans was capable of mounting a specific immune response to protect itself from pathogens. It has only just become clear that this simple nematode in fact possesses a complex innate immune system, involving multiple signalling pathways and an armoury of antimicrobial proteins and peptides. Genetic and microarray approaches are now revealing the molecular cross-talk that exists between the different signalling cascades.
直到最近，人们还不清楚无脊椎动物秀丽隐杆线虫是否能够产生特定的免疫反应来保护自己免受病原体侵害。现在才刚刚清楚，这种简单的线虫实际上拥有一个复杂的先天免疫系统，涉及多个信号通路以及一系列抗菌蛋白和肽。遗传和微阵列方法现在正在揭示不同信号级联之间存在的分子相互作用。
